Urtecho plans to survey genetic variations in two different families of enzymes that bacteria use to shape their local environment to figure out which versions make the intestines a more habitable place for the helpful bacteria. Mosquitoes transmit deadly diseases to humans around the world. Lauren Hagler wants to predict how the structure of RNA inside a cell will affect downstream gene expression for any RNA sequence or mutation. Uncovering what governs NAD+ metabolic flux inside cells may clarify and eventually counter diseases and aging. Lynne Chantranupong knows how to get cells to spill their secrets. Former lab member Abe Sabbarini earns a NSF Graduate Research Fellowship for his work at Harvard in an unknown essential gene, Zpr1. Raji plans to uncover the molecular targets that drive mosquitoes attraction to humans, and the human odors most crucial in activating these targets. However, many bacteria have developed resistance to these antibiotics. By exciting, shutting down, or genetically altering these neurons in mice, Yue will explore their contribution to migraine pain. Worldwide, these bacteria are the leading cause of death from infectious disease, as they are often resistant to existing treatments. Pimentel is interested in how peoples genetic variation affects RNA splicing how cells edit RNA copies of genes. Cagney Coomer is generating transgenic tools which change an organisms DNA for transsynaptic tracing in zebrafish to map, monitor, and manipulate neural circuits. She has received funding through the NIH and the Health Forward Foundation on diabetes prevention projects. Jeffrey J. Lange, Ph.D., is the Senior Research Scientist in the Electron and Light Microscopy Technology Center at the Stowers Institute. Molecular and Cell Biology, Mitochondria provide the energy needed for nerve cells to function, but when aged or damaged, these organelles can potentially be harmful to the cell. This detailed understanding of how cells stymie disease could lead to new strategies for treating infections. Quinton Smith wants to engineer stem cell-derived mini livers in the lab. in physics at Truman State University in Kirksville, Missouri. Watch on Shanice Webster is examining tritrophic interactions among plants, pathogens, and the microbiome to uncover general principles and mechanistic underpinnings of how pathogens and the microbiome influence each other in plant pathogenesis. Virulent human pathogens hijack the cells movement machinery to travel within cells and spread between cells during infection. Our genomes encode thousands of microproteins with mysterious evolutionary origins and functions. Allen plans to uncover novel drivers of the disease and identify pathways that can be targeted by therapeutics. The Graduate School of the Stowers Institute, B.S.,Biology and General Studio Art, University of Miami, Coral GablesPh.D.,Molecular andCellular Biology, Stony Brook University. Stowers Institute. Daniel Gonzales aims to eavesdrop on the chatter between brain cells. Hua Li joined the Stowers Institute in 2006 and completed her postdoctoral training in 2007. Jessica Warren is investigating how the chloroplasts bacterial structures and genetic features have been integrated into modern plant cells, and how this incorporation controls plant development and physiology. James Allen is working to understand how pediatric cancers, such as T-cell acute lymphoblastic leukemia, or T-ALL, co-opt our bodys mechanisms for their own ends. By identifying the targets and effectors of this regulation, Rosa Mercado's work could reveal potential therapeutic targets to treat conditions ranging from neurodegeneration to cancer. Genetics and Genomics, But Snchez-Rivera is particularly interested in mutations that create proteins with new abilities. The team has developed a range of molecular tools to study this animal's regenerative capacity, which is driven by a To transition to the faculty phase of the program, fellows must obtain a tenure-track (or equivalent) faculty position at a U.S. (including Puerto Rico) research institution with a doctoral-level graduate program in their area of interest. Monique Mendes is working to understand how astrocytes specialized cells of the central nervous system coordinate and respond to neuronal activity across brain states and behavior. . Understanding palliative care What is palliative care? While these acids, known as hydroxycinnamic acids, are common in food, they accumulate at high levels in people with failing kidneys. Maria Toro Moreno is investigating whether these rapidly evolving microproteins act as defenses against important pathogens such as HIV and influenza. After creating a collection of protein fibers from scratch, Bethel will test them to learn which molecular interactions give rise to which mechanical properties. He plans to recreate the biliary tree, an essential liver structure that secretes digestive enzymes and exports toxins. Scott Hawley, Ph.D., joined the Stowers Institute in 2001, and is an Investigator for the Institute and Dean Emeritus for the Graduate School. Hawley is a noted researcher for his groundbreaking work on meiosis and a dedicated teacher, having trained more than 400 undergraduates over his career. She has been recognized by Ingrams Magazine as one of Kansas Citys Most Accomplished and Successful Women (2008) and as an Icon of Education (2019). But the neural rules that hold true in mice dont always translate to humans. Gonzales plans to develop an array of nano-sized sensors to record the activity of nerve cell networks at the surface of a mouses brain. Using new genetic tools, she plans to find and manipulate the molecules that control touch sensory neuron development in mice. Using sophisticated tools that can track the molecules metabolic origin and fate, Melanie McReynolds aims to figure out how NAD+ is produced and used up. If you are interested in a research opportunity, please email Kimla. Her work may lead to new ways to prevent disease progression and suggest novel strategies to control infection. Molecular and Cell Biology, DJuan Farmer hopes to establish the origins of vertebrate birth defects. Because direct inhibition of oncogenic RAS has proven very difficult, studying other cellular parameters that promote RAS cancer will likely lead to novel therapies. Using the genetic tool CRISPR to turn down the activity of specific genes and see what changes occur, Jinich hopes to identify and characterize hundreds of unknown enzymes, revealing new drug targets. Systems Biology. His interest in how organs develop prompted a focus on stem cells namely, their life span and maintenance. She received teaching awards in the UMKC internal medicine residency and the endocrinology fellowship in 2018 and 2019. Molecular and Cell Biology, Genetics; Laboratory Rotation; Thesis Laboratory. Systems Biology, Evolution and Model Systems; Laboratory Rotation; Thesis laboratory. Low levels of NAD+ have been linked to both aging and a wide range of diseases, including type-2 diabetes, Alzheimers, and cancer. After building microarray robots at the University of California, Berkeley, and Childrens Hospital of Oakland Research Institute, Seidel joined the Stowers Institute where he develops novel genomic approaches and analysis pipelines and continues to do research in genomics. She is a professor in the Department of Internal Medicine and the Department of Biomedical and Health Informatics at the UMKC School of Medicine. Carter is studying a family of proteins called zinc finger transcription factors that are enriched during this process. Autumn York is investigating how the immune system interacts with the bodys metabolic pathways to control inflammation. Fellows will receive $250,000 in research funding and a $20,000 expense allowance per year, paid through a non-renewable grant to the institution where they have attained a faculty position. Francisco J. Snchez-Rivera plans to comb through human tumor data to systematically identify recurringbut understudiedp53 mutations, and figure out how they wreak havoc in the body. Leah Guthrie is mapping how gut microbes metabolize certain acids found in foods such as apples, pears, and artichokes. She then transitioned to a role as a Research Specialist in Microscopy, where she worked with laboratory researchers throughout the Stowers Institute to plan, perform, analyze and publish imaging experiments to address a wide range of biological questions. Lewallen also led development of the Responsible Conduct of Research course at Stowers. Sick animals often withdraw socially, hiding instead of seeking affection. Hell chase a female, tap her abdomen, and vibrate his wings to produce a courtship song. . The advent of sequencing technologies has revealed a remarkable diversity among the protein families of most known species, yet many of these proteins remain uncharacterized. Just a few kinds of signals control the fates of cells that either maintain their stem cell state, divide or differentiate in a developing organism. All living cells use ribosomes to translate the genetic code into proteins. Hes developing computational frameworks to help design and analyze his collaborators CRISPR-based experiments as well as large genetic data sets from patients. He seeks to build a platform for engineering new biomaterials from antibiotics to polymers. Neuroscience, Gene Expression: Transcription to Translation; Laboratory Rotation; Thesis Laboratory. She aims to understand how these organisms as well as evolutionarily ancient animals including sponges, comb jellies, and sea anemones sense and respond to viruses. In 2021, HHMI expanded our commitment to advance inclusion at key career stages in academic science. Morgan Gilman is scrutinizing a set of molecular mechanisms that nearly all bacteria use to build their cell walls in order to help break them down. A better grasp of the basics could help scientists understand why such mishaps are common in neurodegenerative diseases like Alzheimers and Parkinsons. By Ryan Stowers Higher ed's free speech controversies must be solved on campuses, not in the statehouse. She joined the Institute in 2002 and currently serves as an Investigator. She aims to apply these powerful techniques to study both the developing and regenerating nervous system. HHMI supports people, rather than projects, because its individual scientists who break barriers to advance knowledge. Njomen hopes to develop advanced probes that can be used to ramp the autophagy process up or down for potential use in pharmaceuticals to target pathogens, including drug-resistant strains of bacteria. By pursuing how neurons develop and recover upon microbial insults and inflammation, Aydin hopes to provide insights into neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Parkinsons disease, where pathological inflammation causes neuronal damage. Cox hopes that decoding those cellular signals will lead to novel ways of improving crop yields, and ultimately to feeding more people. Ngoc-Han Tran studies the endoplasmic reticulum a cellular compartment that varies in size and shape and performs a wide range of essential functions throughout its dynamic partitioning in the ovary. Decoding the activity and functions of these organelles and their potential role in disease could provide clues to treatment. Evolutionary Biology, Alejo plans to develop techniques for generating synthetic cells that contain different versions of the ribosome and its molecular partners. It is the largest university of applied sciences in the state of Baden-Wrttemberg, offering both academic and professional higher education study programmes in engineering .
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